Friday, 26 June 2015

PHARMACEUTICAL INORGANIC CHEMISTRY

Well, If you love chemistry, You fall in love with this subject.
If you hate it, trust me your hatred towards chemistry increases.
This subject deals with Various salts which are useful in pharmaceutics.
You're gonna learn properties, Limits, Test for purity and Assay of various salts.

This subject include :

UNIT I 1. Classification of Inorganic Pharmaceuticals based on their applications and therapeutic uses.
2. Sources of impurities in pharmaceutical substances.
3. Test for purity (a) Setting property of plaster of paris
 (b) Ammonium compounds in sodium bicarbonate
(c) Oxalate in sodium citrate.
(d) Barium and thiocynate in Ammonium chloride and
 4. Qualitative tests for anion and cations
5. Limit tests for arsenic, heavy metals, lead, iron, chloride and sulphate.

UNIT II
1. Electrolytes: a. Sodium and potassium replenishers: Sodium chloride, compound sodium chloride solution (Ringer solution), potassium chloride, ORS.
b. Calcium replenishers: Calcium gluconate, dibasic calcium phosphate, calcium chloride.
 2. Acid base regulators: Sodium bicarbonate, sodium lactate, sodium citrate/potassium citrate, sodium acetate, and ammonium chloride
3. Dialysis fluids: Haemodialysis fluids.
UNIT III
Gastro-intestinal agents.
1. Acidifiers and Antacids: Dilute hydrochloric acid, sodium acid phosphate, sodium bicarbonate, aluminium hydroxide gel, dried aluminium hydroxide gel, magnesium oxide (Magnesia), magnesium hydroxide mixture, magnesium trisilicate.
 2. Adsorbents and related drugs: Light kaolin, heavy kaolin, and activated charcoal.
3. Laxatives: Magnesium sulphate, sodium phosphate.
4. Mineral Nutrients / Supplements
(a) Haematinics – Ferrous sulphate, ferrous fumarate, ferrous gluconate, ferric ammonium citrate, iron and dextrose injection.
(b) Halogens: Iodine, Iodides. 5. Pharmaceutical aids:
(a) Excipients: Dicalcium phosphate, magnesium stearate, talc and calcium carbonate (Precipitated chalk).
 (b) Suspending agents: Bentonite, colloidal silica.
(c) Colorants: Titanium oxide, Ferric oxide
UNIT-IV
(a) Expectorants: Ammonium chloride, potassium iodide.
(b) Emetics: Potassium antimony tartarate, copper sulphate.
(c) Antidotes: Sodium thiosulphate, sodium nitrite.
Topical agents:
1) Astringents: Zinc sulphate, calcium hydroxide, Bismuth sub carbonate.
 2) Topical protectants: Zinc oxide, calamine, zinc stearate, talc, titanium- dioxide, heavy kaolin and light kaolin (only uses).
3) Silicone polymers: Activated dimethicone.
 4) Anti-Infectives: Hydrogen peroxide solution, potassium permanganate, silver nitrate (silver protein), iodine, (solutions of iodine, povidone iodine), boric acid, zinc undecylenate, mercury compounds (yellow mercuric chloride)
 UNIT-V
Dental products:
1) Fluorides: Sodium fluoride, sodium monofluorophosphate and stannous fluoride.
2) Oral antiseptics and Astringents: Hydrogen peroxide, magnesium peroxide, zinc peroxide and mouth washes.
 3) Dentifrices: Calcium carbonate, dibasic calcium phosphate, calcium phosphate, sodium metaphosphate and strontium chloride.
 4) Cements & fillers : Zinc oxide (only uses). Miscellaneous Medicinal Agents
a) Antineoplastics : Cisplatin
 b) Antidepressants : Lithium carbonate
c) Diagnostic agents : Barium sulphate
d) Surgical Aids : Plaster of Paris
e) Antirheumatic agents : Sodium aurothiomalate
f) Internal parasiticid : Sodium antimony gluconate g) Anti thyroid agents : Potassium perchlorate


2015 QUESTION PAPER:


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